Person X is a blood type O+ and person Y is a type AB,A,B (+ or -). Man X is injected secretly or covertly by person Y with blood from person Y. The type O+ in man X's blood reacts with the A/AB/B in man Y's blood, and man X dies.
This works because blood has a few types. O+ people can only be injected by O (+ or -). AB+ can be injected by anything.
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